Iron enhances the antituberculous activity of pyrazinamide
نویسندگان
چکیده
منابع مشابه
Iron enhances the antituberculous activity of pyrazinamide.
BACKGROUND Pyrazinamide is a paradoxical frontline tuberculosis drug characterized by high in vivo sterilizing activity but poor in vitro activity. This separation in pyrazinamide activity reflects differences between the in vivo tissue environment and in vitro culture conditions. The well-known acid pH requirement for pyrazinamide activity was discovered previously based on such reasoning but ...
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Activity of pyrazinamide in the guinea pig model of tuberculosis.
Ordway et al. (8) have recently evaluated standard chemotherapy with a combination of rifampin, isoniazid, and pyrazinamide (PZA) in the guinea pig model of tuberculosis (TB) and described long-term bacterial persistence. Soon after the introduction of PZA in 1952, perhaps the most experienced group examining the activity of antituberculosis drugs in the guinea pig model reported that PZA had l...
متن کاملPantothenate and pantetheine antagonize the antitubercular activity of pyrazinamide.
Pyrazinamide (PZA) is a first-line tuberculosis drug that inhibits the growth of Mycobacterium tuberculosis via an as yet undefined mechanism. An M. tuberculosis laboratory strain that was auxotrophic for pantothenate was found to be insensitive to PZA and to the active form, pyrazinoic acid (POA). To determine whether this phenotype was strain or condition specific, the effect of pantothenate ...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2004
ISSN: 1460-2091
DOI: 10.1093/jac/dkh042